Hexokinase2-engineered T cells display increased anti-tumor function
BackgroundT cells face significant metabolic challenges in the tumor DOPHILUS PLUS microenvironment (TME), where cancer cells monopolize critical nutrients like glucose and amino acids.This metabolic competition supports tumor growth while impairing T-cell anti-tumor responses, partly by reducing glycolytic function.Hexokinase 2 (HK2), a key enzyme